ABSTRACT
Fibulin protein family is a class of extracellular matrix (ECM) proteins that are widely expressed in various tissues and plays an important role in the formation and stabilization of ECM. More and more studies have found that Fibulin protein family can play a role in tumor suppression or tumor promotion in different tumor tissues, which affects tumor proliferation, invasion and metastasis and is closely related to tumor chemotherapy resistance. Furthermore, Fibulin protein family is expected to be the target of inhibiting and reversing tumor chemotherapy resistance. This article reviews the role, target and molecular mechanism of Fibulin protein family in tumor development, progression and chemotherapy resistance, aiming to find a new research direction for tumor chemotherapy resistance.